Can preoperative parameters predict successful sperm retrieval and live birth in couples undergoing testicular sperm extraction and intracytoplasmic sperm injection for azoospermia?

Abstract Background We aimed to determine if the success of TESE and live-birth following TESE-ICSI can be predicted from readily available preoperative parameters for couples with azoospermia. Our methodology was as follows, this a cohort study who attended fertility service (from 2009-2019) at an NHS hospital in whom male partner diagnosed azoospermia required conventional multiple biopsies obtain sperm. Of 414 men included, 223 had successful those 178 have used sperm ICSI cycle(s). Predictive models were developed using logistic regression. assessed model performance by internally validated concordance statistics calibration plots. Successful retrieval defined presence motile which survived freeze-thaw process delivery after 34 weeks gestation. Results associated higher age lower FSH. The discriminated well c statistic 0.81 (0.77-0.85). Live-birth maternal age, earlier cycle, testicular volume. also 0.70 (0.64-0.76). Conclusions These results support pragmatic counselling about chances procedure biological parenthood prior surgical intervention. help discriminate between high or low chance achieving TESE. This will allow make better assessment balance risk versus benefit commitment interventions.